Keith Callenberg, Ph.D.


Associate Director, Machine Learning, Thrive Earlier Detection, 2020-Present

Director, Machine Learning, UPMC Enterprises, 2017-2020

Lead Bioinformatics Scientist, University of Pittsburgh Medical Center, 2015-2017

Sr. Clinical Research Scientist, Interpace Diagnostics, 2013-2015

Graduate Student Researcher, Carnegie Mellon University-University of Pittsburgh, 2008-2013

Research Assistant, Iowa State University, 2007-2008

Software Engineer, Evocative, Inc., 2005-2007


Ph.D. Computational Biology, 2013, Carnegie Mellon University-University of Pittsburgh, Pittsburgh, PA

B.S. Computer Science, 2008, San Jose State University, San Jose, CA


  • Sanghvi, A.B., Allen, E.Z., Callenberg, K.M., Pantanowitz, L. (2019) Performance of an artificial intelligence algorithm for reporting urine cytopathology. Cancer Cytopathology 127 (10), 658-666

  • Wang, M., Callenberg, K.M., Dalgleish, R., Fedtsov, A., Fox, N.K., Freeman, P.J., Jacobs, K.B., Kaleta, P., McMurry, A.J., Prlić, A., Rajaraman, V., Hart, R.K. (2018) HGVS: A Python package for manipulating sequence variants using HGVS nomenclature: 2018 Update. Human Mutation 39 (12), 1803-1813

  • Nikiforova, M.N., Mercurio, S., Wald, A.I., Barbi de Moura, M., Callenberg, K.M., Santana-Santos, L., Gooding, W.E., Yip, L., Ferris, R.L., Nikiforov, Y.E. (2018). Analytical performance of the ThyroSeq v3 genomic classifier for cancer diagnosis in thyroid nodules. Cancer

  • Guerriero, C., Richard-Reutter, K., Augustine, A., Preston, G., Weiberth, K., Mackie, T., Cleveland-Rubeor, H., Bethel, N., Callenberg, K.M., Nakatsukasa, K., Grabe, M., Brodsky, J. (2017). Energetic barriers to the retrotranslocation of integral membrane ERAD substrates. Molecular Biology of the Cell 28 (15):2076-2090

  • Eluri, S., Brugge, W.R., Daglilar, E.S., Jackson, S.A., Styn, M.A., Callenberg, K.M., Welch, D.C., Barr, T.M., Duits, L.C., Bergman, J.J., Shaheen, N.J. (2015). The presence of genetic mutations at key loci predicts progression to esophageal adenocarcinoma in Barrett’s esophagus. American Journal of Gastroenterology. In press.

  • Mukherjee, S., Zheng, H., Derebe, M., Callenberg, K.M., Partch, C.L., Rollins, D., Propheter, D.C., Rizo, J., Grabe, M., Jiang, Q., Hooper, L.V. (2014). Antibacterial membrane attack by a pore-forming intestinal C-type lectin. Nature 505: 103-107. doi:10.1038/nature12729.

  • Latorraca, N.R.*, Callenberg, K.M.*, Boyle, J.P., Grabe, M. (2013). Continuum approaches to understanding ion and peptide interactions with the membrane. Journal of Membrane Biology 247 (5): 395-408. * co-first authors

  • Callenberg, K.M., Latorraca, N.R., Grabe, M. (2012). Membrane bending is critical for the stability of voltage sensor segments in the membrane. Journal of General Physiology 140 (1): 55. doi: 10.1085/jgp.201110766.

  • Callenberg, K.M., Choudhary, O.P., De Forest, G., Gohara, D., Baker, N., Grabe, M. (2010). APBSmem: A graphical interface for electrostatics calculations at the membrane. PLoS ONE 5(9): e12722. doi:10.1371/journal.pone.0012722

  • Couture, O., Callenberg, K.M., Koul, N., Pandit, S., Younes, J., Hu, Z-L., Dekkers, J., Reecy, J., Honavar, V., and Tuggle, C. (2009). ANEXdb: An Integrated Animal ANnotation and Microarray EXpression Database. Mammalian Genome. doi:10.1007/s00335-009-9234-1